Potassium Carbonate → HCID 71236550, compound

HRID 2407173Notes

Reaction equation

HRID 2407173 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[CH3:15][C:16]1[CH:17]=[N:18][CH:19]=[C:20]([CH3:23])[C:21]=1[OH:22].C([O-])([O-])=O.[K+].[K+]>>[NH2:8][C:5]1[N:6]=[N:7][C:2]([N:18]2[CH:19]=[C:20]([CH3:23])[C:21](=[O:22])[C:16]([CH3:15])=[CH:17]2)=[C:3]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:4]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amineHCID 178430492HCID 178430492, compound

Product 1

HCID 71236550HCID 71236550, compoundYield 5.1%

Procedure

1-(3-Amino-5-phenyl-1,2,4-triazin-6-yl)-3,5-dimethylpyridin-4(1H)-one (40 mg, 5%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.70 g, 2.7 mmol), 3,5-dimethylpyridin-4-ol (0.45 g, 3.7 mmol) and K2CO3 (0.93 g, 6.7 mmol) according to the general procedure of Example 3.

Sources & evidence

ORD record
ord-b680a56a8d6b467fadd317053f44a50a
Source dataset
uspto-grants-2014_08
Patent number
US08809525B2

Reaction notes

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