Trifluoroacetic acid → 4-Amino-1-methylpiperazin-2-one 2,2,2-trifluoroacetate

HRID 240723Notes

Reaction equation

HRID 240723 reaction equation
C(OC(=O)[NH:7][N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[C:10](=[O:15])[CH2:9]1)(C)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[NH2:7][N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[C:10](=[O:15])[CH2:9]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71294329(4-Methyl-3-oxo-piperazin-1-yl)-carbamic acid t-butyl ester

Product 1

HCID 712943164-Amino-1-methylpiperazin-2-one 2,2,2-trifluoroacetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

(4-Methyl-3-oxo-piperazin-1-yl)-carbamic acid t-butyl ester (67 mg, 292 μmol) was at 0° C. combined with dichloromethane (2 mL) and trifluoroacetic acid (1 mL) to give a light yellow solution. The reaction mixture was stirred for 2 h at 0° C. and subsequently concentrated in vacuo to give the title compound as yellow oil, which was used without further purification in the next step.

Workup

  1. customwas at 0° C.
  2. customto give a light yellow solution
  3. concentrationsubsequently concentrated in vacuo

Sources & evidence

ORD record
ord-8ad12926f3fc4fe9896de6257f42e62d
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Reaction notes

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