Trifluoroacetic acid → 3-((Tert-butyldimethylsilyl)oxy)azetidin-1-amine 2,2,2-trifluoroacetate

Participants

Reaction Conditions

Reaction Steps

[3-(t-Butyl-dimethyl-silanyloxy)-azetidin-1-yl]-carbamic acid t-butyl ester (100 mg, 331 mmol) was at 0° C. combined with trifluoroacetic acid (2 mL) to give a colorless solution. The reaction mixture was stirred for 2 h at 0° C. and subsequently concentrated in vacuo to give the title compound as colorless oil, which was used without further purification in the next step.

Provenance & Evidence