反应详情

温度

66 °C

To a suspension of LiAlH4 (0.62 g, 16.30 mmol) in dry THF (15 ml) was added 1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)-piperidine-3-carboxylic acid amide (0.45 g, 01.63 mmol) in dry THF (5 ml). The reaction mixture was heated under microwaves at 66° C. for 1 h. Water was slowly added and the mixture extracted with EtOAc (3×20 ml). The combined organic phases were dried (Na2SO4), filtered and the filtrate was evaporated to give the desired product, which was purified by column chromatography (DCM/MeOH, 98:2).

1. extractionthe mixture extracted with EtOAc (3×20 ml)
2. dry with materialThe combined organic phases were dried (Na2SO4)
3. filtrationfiltered
4. customthe filtrate was evaporated