反应详情

(S)-1-Benzyl-3-methyl-3-[2-(tetrahydropyran-2-yloxy)ethoxymethyl]piperidine (1.14 g, 3.3 mmol) in MeOH (11 ml) was added to a suspension of Pd/C (0.23 g) in MeOH (11 ml), followed by ammonium formate (1.03 g, 16.4 mmol). The mixture was refluxed for 2 h, after which it was cooled and filtered through Celite. The catalyst was washed with DCM and the combined organic phases were evaporated to dryness. To the residue was added brine (15 ml) and the solution was extracted with EtOAc (3×30 ml). The extracts were combined, dried, filtered and evaporated to yield 0.71 g of the debenzylated product.

1. temperatureThe mixture was refluxed for 2 h
2. temperatureafter which it was cooled
3. filtrationfiltered through Celite
4. washThe catalyst was washed with DCM
5. customthe combined organic phases were evaporated to dryness
6. additionTo the residue was added brine (15 ml)
7. extractionthe solution was extracted with EtOAc (3×30 ml)
8. customdried
9. filtrationfiltered
10. customevaporated