4-Amino-1lambda~6~,4-thiazinane-1,1-dione → 5-cyclopropyl-N-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

HRID 240732Notes

Reaction equation

HRID 240732 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[N:6][CH:7]=[C:8]([CH:12]=2)[C:9]([OH:11])=O)[CH2:3][CH2:2]1.[O:19]=[S:20]1(=[O:27])[CH2:25][CH2:24][N:23]([NH2:26])[CH2:22][CH2:21]1>>[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[N:6][CH:7]=[C:8]([CH:12]=2)[C:9]([NH:26][N:23]2[CH2:24][CH2:25][S:20](=[O:27])(=[O:19])[CH2:21][CH2:22]2)=[O:11])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 127082634-Amino-1lambda~6~,4-thiazinane-1,1-dioneHCID 712941085-Cyclopropyl-6-(2,2,2-trifluoroethoxy)nicotinic acid

Product 1

HCID 712940035-cyclopropyl-N-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Procedure

The title compound was synthesized in analogy to the procedure described in Example 34 c), using 5-cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (example 34b) and 1,1-dioxo-1λ6-thiomorpholin-4-ylamine as starting materials (CAN 26494-76-8); MS (ESI) 394.4 (M+H)+.

Sources & evidence

ORD record
ord-56f1400c46a84c85894fbe31dfafb11e
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Reaction notes

Loading…