HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-1lambda~6~,4-thiazinane-1,1-dione → 5-cyclopropyl-N-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-1lambda~6~,4-thiazinane-1,1-dione | HCID 12708263 | — |
| Reactant | 5-Cyclopropyl-6-(2,2,2-trifluoroethoxy)nicotinic acid | HCID 71294108 | — |
| Product | 5-cyclopropyl-N-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide | HCID 71294003 | — |
Reaction Steps
The title compound was synthesized in analogy to the procedure described in Example 34 c), using 5-cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (example 34b) and 1,1-dioxo-1λ6-thiomorpholin-4-ylamine as starting materials (CAN 26494-76-8); MS (ESI) 394.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648099B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-56f1400c46a84c85894fbe31dfafb11e |
| Source note | uspto-grants-2014_02 |