N-Aminomorpholine → 5-cyclopropyl-N-morpholin-4-yl-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

HRID 240733Notes

Reaction equation

HRID 240733 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[N:6][CH:7]=[C:8]([CH:12]=2)[C:9]([OH:11])=O)[CH2:3][CH2:2]1.[N:19]1([NH2:25])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[N:6][CH:7]=[C:8]([CH:12]=2)[C:9]([NH:25][N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)=[O:11])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 20315N-AminomorpholineHCID 712941085-Cyclopropyl-6-(2,2,2-trifluoroethoxy)nicotinic acid

Product 1

HCID 712944005-cyclopropyl-N-morpholin-4-yl-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Procedure

The title compound was synthesized in analogy to the procedure described in Example 34 c), using 5-cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (example 34b) and morpholin-4-ylamine as starting materials (CAN 4319-49-7); MS (ESI) 346.4 (M+H)+.

Sources & evidence

ORD record
ord-9aee94d2b5ae4e5c9346a72e99bdb45d
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Reaction notes

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