Caprolactam → 6-Aminohexanoic Acid

HRID 2407610Notes

Reaction equation

HRID 2407610 reaction equation
[C:1]1(=[O:8])[NH:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-:9].[Na+]>Cl>[CH2:4]([CH2:5][CH2:6][NH2:7])[CH2:3][CH2:2][C:1]([OH:8])=[O:9]

Participants

4

Reactant 2

HCID 7768CaprolactamHCID 14798Sodium Hydroxide

Product 1

HCID 5646-Aminohexanoic Acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

5 g of ε-caprolactam was dissolved in 10% HCl (20 g) and heated to reflux until the starting material was reacted completely. The pH of the mixture was adjusted to 7.6 by adding 10% NaOH(aq). The mixture was concentrated at 55° C. and then recrystallized in methanol to obtain aminocaproic acid containing inorganic salts.

Workup

  1. temperatureheated
  2. temperatureto reflux until the starting material
  3. customwas reacted completely
  4. concentrationThe mixture was concentrated at 55° C.
  5. customrecrystallized in methanol

Sources & evidence

ORD record
ord-4bdf9512abbb499a8dd325d7e8b0ffd8
Source dataset
uspto-grants-2014_08
Patent number
US08809581B2

Reaction notes

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