反应详情

Trifluoroacetic acid (2.1 mL) was added to a room temperature solution of the compound prepared in Example 8 (0.99 g) in dichloromethane (10 mL). The reaction was stirred overnight and then concentrated. The crude residue was azeotroped with a solution of hexane and toluene, diluted with ethyl acetate and washed with an aqueous 10% sodium carbonate solution. The organics were dried over anhydrous magnesium sulfate and concentrated to obtain the title compound (0.60 g) having the following physical data.

1. concentrationconcentrated
2. customThe crude residue was azeotroped with a solution of hexane and toluene
3. additiondiluted with ethyl acetate
4. washwashed with an aqueous 10% sodium carbonate solution
5. dry with materialThe organics were dried over anhydrous magnesium sulfate
6. concentrationconcentrated