Trifluoroacetic acid → HCID 66989233, compound

HRID 2407662Notes

Reaction equation

HRID 2407662 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)=[O:7])=[CH:4][C:3]=1[O:25][CH3:26].[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30]>ClCCl>[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30].[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)=[O:7])=[CH:4][C:3]=1[O:25][CH3:26]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58504140HCID 58504140, compound

Product 1

HCID 66989233HCID 66989233, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of the compound prepared in Example 10 (1.44 g) in dichloromethane (8.04 mL)-trifluoroacetic acid (1.46 mL) was stirred for 18 hours. The reaction was concentrated and the excess trifluoroacetic acid was removed via azeotropic distillation from toluene and diethyl ether. The resulting oil solidified upon treatment with (diethyl ether:hexane=5:1) and the solids were collected by filtration to obtain the title compound (1.36 g) having the following physical data.

Workup

  1. concentrationThe reaction was concentrated
  2. customthe excess trifluoroacetic acid was removed via azeotropic distillation from toluene and diethyl ether
  3. filtrationthe solids were collected by filtration

Sources & evidence

ORD record
ord-9275adbbd8cf4154967a8f60fc20f953
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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