反应详情

A solution of the compound prepared in Example 7 (500 mg), ethyl 2-(piperidin-4-yl)acetate (494 mg) and acetic acid (0.33 mL) in acetonitrile (15 mL) was stirred for 30 minutes at room temperature. Tetramethylammonium triacetoxyborohydride (2.28 g) was added and the reaction was stirred overnight. The reaction was poured into a saturated aqueous sodium bicarbonate solution and was extracted three times with ethyl acetate. The organic phases were combined, dried over anhydrous magnesium sulfate and concentrated to obtain the title compound (675 mg) having the following physical data.

1. extractionwas extracted three times with ethyl acetate
2. dry with materialdried over anhydrous magnesium sulfate
3. concentrationconcentrated