4-Phenyl-3,4-dihydroisoquinolin-1(2H)-one → HCID 66989293, compound

HRID 2407679Notes

Reaction equation

HRID 2407679 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:18][CH2:17][N:16]([CH2:19][C:20]3[O:24][N:23]=[C:22]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH:21]=3)[CH2:15][CH2:14]2)(=O)=O)=CC=1.[C:31]1([CH:37]2[C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[C:40](=[O:47])[NH:39][CH2:38]2)[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1.ClC1C=C2C(=CC=1)C(=O)NCC2>>[C:31]1([CH:37]2[C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[C:40](=[O:47])[N:39]([CH2:12][CH:13]3[CH2:14][CH2:15][N:16]([CH2:19][C:20]4[O:24][N:23]=[C:22]([C:25]5[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=5)[CH:21]=4)[CH2:17][CH2:18]3)[CH2:38]2)[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

Participants

4

Reactant 3

HCID 124033084-Phenyl-3,4-dihydroisoquinolin-1(2H)-oneHCID 193756376-Chloro-3,4-dihydroisoquinolin-1(2H)-oneHCID 86659055HCID 86659055, compound

Product 1

HCID 66989293HCID 66989293, compound

Procedure

According to the same procedure described in Example 61, using the compound prepared in Example 65 instead of tert-butyl 4-(bromomethyl)piperidine-1-carboxylate and 4-phenyl-3,4-dihydroisoquinolin-1(2H)-one (prepared according to the reported preparation in Davies, R. V.; et al. J. Chem. Soc. Perkin Trans. 1 1978, 180) instead of 6-chloro-3,4-dihydroisoquinolin-1(2H)-one, the title compound having the following physical data was obtained.

Workup

  1. customprepared
  2. customaccording to the reported preparation in Davies, R

Sources & evidence

ORD record
ord-2b2eaeb665a0427fa46ccf45c790b652
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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