Hydrochloric Acid → HCID 66989455, compound

HRID 2407703Notes

Reaction equation

HRID 2407703 reaction equation
[C:1]1([C:7]2[CH:11]=[C:10]([C:12]([OH:14])=[O:13])[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:15].[CH3:16]O>>[ClH:15].[C:1]1([C:7]2[CH:11]=[C:10]([C:12]([O:14][CH3:16])=[O:13])[NH:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 121025Pyrazole-5-carboxylic acid, 3-phenyl-

Product 1

HCID 66989455HCID 66989455, compound

Procedure

3-Phenyl-1H-pyrazole-5-carboxylic acid (4.96 g) was suspended in methanol (80 mL) and concentrated hydrochloric acid (22.0 mL) and the reaction mixture heated at reflux overnight. Upon cooling the title compound (3.00 g) precipitated from the reaction mixture, was filtered and dried under vacuum. The material was used without further purification having the following physical data.

Workup

  1. temperatureat reflux overnight

Sources & evidence

ORD record
ord-007dce2804b54a079eeb01c6690b0d7f
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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