Hydrochloric Acid → HCID 66989456, compound

HRID 2407731Notes

Reaction equation

HRID 2407731 reaction equation
C(OC([NH:8][C:9]1[S:13][C:12]([C:14]([O:16][CH2:17][CH:18]2[CH2:23][CH2:22][N:21]([CH2:24][C:25]3[S:29][C:28]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=4)=[N:27][CH:26]=3)[CH2:20][CH2:19]2)=[O:15])=[C:11]([CH3:36])[C:10]=1[C:37]#[N:38])=O)(C)(C)C.[ClH:39]>CO.ClCCl>[ClH:39].[ClH:39].[ClH:39].[NH2:8][C:9]1[S:13][C:12]([C:14]([O:16][CH2:17][CH:18]2[CH2:19][CH2:20][N:21]([CH2:24][C:25]3[S:29][C:28]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=4)=[N:27][CH:26]=3)[CH2:22][CH2:23]2)=[O:15])=[C:11]([CH3:36])[C:10]=1[C:37]#[N:38]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66990601HCID 66990601, compound

Product 1

HCID 66989456HCID 66989456, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

The compound prepared in Example 223 (0.026 g) was suspended in methanol (2 mL) and dichloromethane (2 mL). Hydrogen chloride solution (4 M in 1,4-dioxane) (3.0 mL) was added and the reaction mixture stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure to afford the title compound (0.027 g), which was used without further purification possessing the following physical data.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-50112e084fd84a9286b9bac3d1707737
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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