Hydrochloric Acid → HCID 66989793, compound

HRID 2407733Notes

Reaction equation

HRID 2407733 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:10][CH2:11][CH3:12])[N:5]=[C:4]([C:13]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)=[O:14])[CH:3]=1.[ClH:30]>ClCCl.CO>[ClH:30].[ClH:30].[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:10][CH2:11][CH3:12])[N:5]=[C:4]([C:13]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)=[O:14])[CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58504102HCID 58504102, compound

Product 1

HCID 66989793HCID 66989793, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

The compound prepared in Example 225 (0.603 g) was suspended in dichloromethane (30 mL) and methanol (10 mL). Hydrogen chloride solution (4 mol/L in 1,4-dioxane) (10.0 mL) was added and the reaction mixture stirred at room temperature for 6 hours. The reaction mixture was concentrated under reduced pressure to afford the title compound (0.547 g), which was used without further purification, possessing the following physical data.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-1ad2197bee6440e3b43e77ca7c635dfe
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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