Trifluoroacetic acid → HCID 86659060, compound

HRID 2407752Notes

Reaction equation

HRID 2407752 reaction equation
[OH:1][C:2]1([CH2:20][NH:21]C(=O)OC(C)(C)C)[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[S:13][C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)=[N:11][CH:10]=2)[CH2:4][CH2:3]1.[F:29][C:30]([F:35])([F:34])[C:31]([OH:33])=[O:32]>ClCCl>[F:29][C:30]([F:35])([F:34])[C:31]([OH:33])=[O:32].[F:29][C:30]([F:35])([F:34])[C:31]([OH:33])=[O:32].[NH2:21][CH2:20][C:2]1([OH:1])[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[S:13][C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)=[N:11][CH:10]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 70667976HCID 70667976, compound

Product 1

HCID 86659060HCID 86659060, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of the compound prepared in Example 252 (0.108 g) in dichloromethane (1.3 mL) was treated with trifluoroacetic acid (0.3 mL) at room temperature for 18 hours. The solvent was evaporated in vacuo and the residue was azeotroped from toluene twice to obtain the title compound (0.104 g) having the following physical data.

Workup

  1. customThe solvent was evaporated in vacuo
  2. customthe residue was azeotroped from toluene twice

Sources & evidence

ORD record
ord-10d7b58de9144216adf39f93beb97aa1
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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