Ethanol → HCID 58503990, compound

HRID 2407772Notes

Reaction equation

HRID 2407772 reaction equation
[O-:1][CH2:2][CH3:3].[Na+].Cl[C:6]1[N:14]=[C:13](Cl)[CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=[O:9].[CH2:16]([OH:18])[CH3:17]>>[CH2:2]([O:1][C:6]1[N:14]=[C:13]([O:18][CH2:16][CH3:17])[CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=[O:9])[CH3:3]

Participants

4

Reactant 3

HCID 702EthanolHCID 8540472,6-Dichloronicotinic acidHCID 2723922Sodium ethoxide

Product 1

HCID 58503990HCID 58503990, compound

Conditions

Temperature
170 °C

Procedure

A solution of sodium ethoxide (23.3 mL) was added to a solution of 2,6-dichloronicotinic acid (2.00 g) in ethanol (10 mL). The mixture was heated in a sealed vessel at 170° C. for 1 day. After cooling, the mixture was concentrated in vacuo and the residue taken in water and acidified with hydrochloric acid to pH 3. The precipitated solids were collected by filtration and washed with water to obtain the title compound (1.75 g) having the following physical data.

Workup

  1. temperatureAfter cooling
  2. concentrationthe mixture was concentrated in vacuo
  3. filtrationThe precipitated solids were collected by filtration
  4. washwashed with water

Sources & evidence

ORD record
ord-b15c995e4ae64361ac2effe53b0f2d43
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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