Hydrochloric Acid → HCID 66989940, compound

HRID 2407780Notes

Reaction equation

HRID 2407780 reaction equation
[O:1]=[C:2]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[NH:24]C1C=CC=CC=1)[CH2:3][CH2:4][CH:5]1[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1.[ClH:31]>CO.O1CCOCC1>[ClH:31].[ClH:31].[NH2:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:2](=[O:1])[CH2:3][CH2:4][CH:5]1[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58504041HCID 58504041, compound

Product 1

HCID 66989940HCID 66989940, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of the compound prepared in Example 303 (1.00 g) in methanol (10 mL) was treated with hydrogen chloride solution in 1,4-dioxane (4 mol/L; 7.52 mL) and stirred at room temperature for 18 hours. The solution was concentrated under reduced pressure and azeotropped from methanol several times to furnish the title compound (0.76 g), which was used without further purification, possessing the following physical data.

Workup

  1. concentrationThe solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c4b3c91d6d4d479abfb959ee9d04521e
Source dataset
uspto-grants-2014_08
Patent number
US08809538B2

Reaction notes

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