反应详情

温度

160 °C

The compound prepared in Example 407 (0.065 g) and 2-aminoethanol (0.008 g) were suspended in dimethyl acetamide (3 mL) and heated at 160° C. for 30 minutes. The reaction mixture was heated at 200° C. for 1 hour. The reaction mixture was cooled to room temperature and partitioned between saturated aqueous sodium bicarbonate and ethyl acetate. The organics were washed with brine, dried, magnesium sulfate and concentrated under reduced pressure to afford the crude material. The crude material was purified by flash column chromatography (eluant: 1-4% (9:1=methanol:ammonium hydroxide)/ethyl acetate) to furnish the title compound (0.037 g), possessing the following physical data.

1. temperatureThe reaction mixture was heated at 200° C. for 1 hour
2. temperatureThe reaction mixture was cooled to room temperature
3. custompartitioned between saturated aqueous sodium bicarbonate and ethyl acetate
4. washThe organics were washed with brine
5. customdried
6. concentrationmagnesium sulfate and concentrated under reduced pressure
7. customto afford the crude material
8. customThe crude material was purified by flash column chromatography (eluant: 1-4% (9:1=methanol:ammonium hydroxide)/ethyl acetate)