反应详情

To a stirred solution of the compound prepared in Example 422 (2.2 g) in tetrahydrofuran (40 mL) was added sodium periodate (5.95 g) in water (40 mL). The mixture was stirred at room temperature overnight. The suspended inorganic solids were filtered out, washed with tetrahydrofuran and the filtrate evaporated in vacuo. The residue was taken in small amount of water and extracted with chloroform, dried, evaporated in vacuo to a brown oil and further dried under high vacuum to afford the title compound (1.6 g) with the following physical data.

1. filtrationThe suspended inorganic solids were filtered out
2. washwashed with tetrahydrofuran
3. customthe filtrate evaporated in vacuo
4. extractionextracted with chloroform
5. customdried
6. customevaporated in vacuo to a brown oil
7. customfurther dried under high vacuum