(1-((2-(Pyridin-2-yl)thiazol-5-yl)methyl)piperidin-4-yl)methanamine Trihydrochloride → 3-amino-4-chloro-6-ethoxy-N-((1-((2-(pyridin-2-yl)thiazol-5-yl)methyl)piperidin-4-yl)methyl)picolinamide
Reaction equation
[NH2:1][C:2]1[C:3]([C:12]([OH:14])=O)=[N:4][C:5]([O:9][CH2:10][CH3:11])=[CH:6][C:7]=1[Cl:8].Cl.Cl.Cl.[N:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24]1[S:25][C:26]([CH2:29][N:30]2[CH2:35][CH2:34][CH:33]([CH2:36][NH2:37])[CH2:32][CH2:31]2)=[CH:27][N:28]=1>>[NH2:1][C:2]1[C:3]([C:12]([NH:37][CH2:36][CH:33]2[CH2:34][CH2:35][N:30]([CH2:29][C:26]3[S:25][C:24]([C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][N:18]=4)=[N:28][CH:27]=3)[CH2:31][CH2:32]2)=[O:14])=[N:4][C:5]([O:9][CH2:10][CH3:11])=[CH:6][C:7]=1[Cl:8]Participants
3
Procedure
According to the same procedure described in Example 16, using the compound prepared in Example 428 instead of 4-chloro-3-methoxybenzoic acid and the compound prepared in Example 214 instead of the compound prepared in Example 9, the title compound having the following physical data was obtained.
Sources & evidence
- ORD record
- ord-21bff0ab4c444796badded36b4135628
- Source dataset
- uspto-grants-2014_08
- Patent number
- US08809538B2
Reaction notes
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