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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2407824Generated: November 2, 2026

(1-((2-(Pyridin-2-yl)thiazol-5-yl)methyl)piperidin-4-yl)methanamine Trihydrochloride → 3-amino-4-chloro-6-ethoxy-N-((1-((2-(pyridin-2-yl)thiazol-5-yl)methyl)piperidin-4-yl)methyl)picolinamide

https://huagongshe.com/reaction/2407824

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(1-((2-(Pyridin-2-yl)thiazol-5-yl)methyl)piperidin-4-yl)methanamine TrihydrochlorideHCID 66989375—
Reactant3-amino-4-chloro-6-ethoxypicolinic AcidHCID 66990081—
Product3-amino-4-chloro-6-ethoxy-N-((1-((2-(pyridin-2-yl)thiazol-5-yl)methyl)piperidin-4-yl)methyl)picolinamideHCID 58504013—

Reaction Steps

According to the same procedure described in Example 16, using the compound prepared in Example 428 instead of 4-chloro-3-methoxybenzoic acid and the compound prepared in Example 214 instead of the compound prepared in Example 9, the title compound having the following physical data was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08809538B2
Source datasetuspto-grants-2014_08
ORD IDord-21bff0ab4c444796badded36b4135628
Source noteuspto-grants-2014_08