3-amino-4,5-dichloro-6-ethoxypicolinic Acid → 3-amino-4,5-dichloro-6-ethoxy-N-((1-((2-(pyridin-2-yl)thiazol-5-yl)methyl)piperidin-4-yl)methyl)picolinamide
Reaction equation
[NH2:1][C:2]1[C:3]([C:13]([OH:15])=O)=[N:4][C:5]([O:10][CH2:11][CH3:12])=[C:6]([Cl:9])[C:7]=1[Cl:8].Cl.Cl.Cl.[N:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25]1[S:26][C:27]([CH2:30][N:31]2[CH2:36][CH2:35][CH:34]([CH2:37][NH2:38])[CH2:33][CH2:32]2)=[CH:28][N:29]=1>>[NH2:1][C:2]1[C:3]([C:13]([NH:38][CH2:37][CH:34]2[CH2:35][CH2:36][N:31]([CH2:30][C:27]3[S:26][C:25]([C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][N:19]=4)=[N:29][CH:28]=3)[CH2:32][CH2:33]2)=[O:15])=[N:4][C:5]([O:10][CH2:11][CH3:12])=[C:6]([Cl:9])[C:7]=1[Cl:8]Participants
3
Procedure
According to the same procedure described in Example 16, using the compound prepared in Example 431 instead of 4-chloro-3-methoxybenzoic acid and the compound prepared in Example 214 instead of the compound prepared in Example 9, the title compound having the following physical data was obtained.
Sources & evidence
- ORD record
- ord-41e99f11091642f688451a2655057fef
- Source dataset
- uspto-grants-2014_08
- Patent number
- US08809538B2
Reaction notes
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