Triethyl Phosphate → HCID 15260324, compound

HRID 2407848Notes

Reaction equation

Br[CH2:2][CH2:3][O:4][CH2:5][CH2:6][Br:7].[P:8](OCC)([O:13][CH2:14][CH3:15])([O:10][CH2:11][CH3:12])=[O:9]>>[Br:7][CH2:6][CH2:5][O:4][CH2:3][CH2:2][P:8](=[O:9])([O:13][CH2:14][CH3:15])[O:10][CH2:11][CH3:12]

Participants

Reactant 2

HCID 6535Triethyl Phosphate

HCID 21521Bis(2-bromoethyl) ether

Product 1

HCID 15260324HCID 15260324, compound

Conditions

Temperature: 160 °C

Procedure

1-bromo-2-(2-bromoethoxy) ethane (1.0 eq) was mixed with triethyl phosphate (1 eq) then heated to 160° C. for 20 minutes by microwave. The crude mixture was purified by flash chromatography on a COMBIFLASH® system (ISCO) using 70-100% EtOAc/Hex to give the product as a colorless oil.

Workup

customThe crude mixture was purified by flash chromatography on a COMBIFLASH® system (ISCO)

Sources & evidence

ORD record: ord-473483d66c544ce0811ca5fd9ff78dae
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08808703B2

Reaction notes

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