HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2407931Generated: October 31, 2026
Piperidine → diethyl((14R,18R)-14-amino-18-dodecanamido-13-oxo-3,6,9,20-tetraoxa-16-thia-12-azadotriacontyl)phosphonate
https://huagongshe.com/reaction/2407931
Participants
| Role | Name | HCID | Charge |
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| Reactant | Piperidine | HCID 8082 | — |
| Reactant | (9H-fluoren-9-yl)methyl((14R,18R)-1-(diethoxyphosphoryl)-18-dodecanamido-13-oxo-3,6,9,20-tetraoxa-16-thia-12-azadotriacontan-14-yl)carbamate | HCID 86678311 | — |
| Solvent | tetrahydrofuran N,N-dimethylformamide | HCID 21974620 | — |
| Product | diethyl((14R,18R)-14-amino-18-dodecanamido-13-oxo-3,6,9,20-tetraoxa-16-thia-12-azadotriacontyl)phosphonate | HCID 86678310 | — |
Reaction Steps
To a solution of ((9H-fluoren-9-yl)methyl((14R,18R)-1-(diethoxyphosphoryl)-18-dodecanamido-13-oxo-3,6,9,20-tetraoxa-16-thia-12-azadotriacontan-14-yl)carbamate (1 eq) was added 20% piperidine (50 eq) in 4:1 THF/DMF. The resulting solution was stirred for 15 minutes at 25° C. and then concentrated en vaccuo. The crude mixture was purified by flash chromatography on a COMBIFLASH® system (ISCO) using 0-10% MeOH/DCM to give the title product as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08808703B2 |
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| Source dataset | uspto-grants-2014_08 |
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| ORD ID | ord-9a359ea0d69a4ee6b2966cf460baf7a2 |
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| Source note | uspto-grants-2014_08 |
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