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HRID2407931

反应详情

EQUATION

反应方程式

HRID 2407931 的结构方程式

REACTANTS

反应物

2
结构：C1CCNCC1
HCID8082

Piperidine

C5H11N

结构：CCCCCCCCCCCCOC[C@H](CSC[C@@H](C(=O)NCCOCCOCCOCCP(=O)(OCC)OCC)N(C)C(=O)OC1c2ccccc2-c2ccccc21)NC(=O)CCCCCCCCCCC
HCID86678311

未命名化合物

PRODUCTS

生成物

1
结构：CCCCCCCCCCCCOC[C@H](CSC[C@H](N)C(=O)NCCOCCOCCOCCP(=O)(OCC)OCC)NC(=O)CCCCCCCCCCC
HCID86678310

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1.CN(C)C=O
溶剂HCID21974620

未命名化合物

CONDITIONS

反应条件

温度
25 °C

PROCEDURE

实验过程

To a solution of ((9H-fluoren-9-yl)methyl((14R,18R)-1-(diethoxyphosphoryl)-18-dodecanamido-13-oxo-3,6,9,20-tetraoxa-16-thia-12-azadotriacontan-14-yl)carbamate (1 eq) was added 20% piperidine (50 eq) in 4:1 THF/DMF. The resulting solution was stirred for 15 minutes at 25° C. and then concentrated en vaccuo. The crude mixture was purified by flash chromatography on a COMBIFLASH® system (ISCO) using 0-10% MeOH/DCM to give the title product as a white solid.

WORKUP

后处理

  1. concentrationconcentrated en vaccuo
  2. customThe crude mixture was purified by flash chromatography on a COMBIFLASH® system (ISCO)