Ammonium Chloride → HCID 62414910, compound

HRID 2407993Notes

Reaction equation

HRID 2407993 reaction equation
[CH:1]1([NH:5][S:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=2)(=[O:8])=[O:7])[CH2:4][CH2:3][CH2:2]1.[Cl-].[NH4+]>O.[Fe]>[NH2:15][C:12]1[CH:13]=[CH:14][C:9]([S:6]([NH:5][CH:1]2[CH2:4][CH2:3][CH2:2]2)(=[O:8])=[O:7])=[CH:10][CH:11]=1

Participants

5

Reactant 2

HCID 25517Ammonium ChlorideHCID 22326749HCID 22326749, compound

Product 1

HCID 62414910HCID 62414910, compoundYield 93%

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 962WaterSolvent

Procedure

To a stirred solution of N-cyclobutyl-4-nitro-benzenesulfonamide (5.8 g, 18.4 mmol) ethanol (400 mL) was added iron powder (5.2 g, 92.0 mmol) and the solution of ammonium chloride (10 g, 184.0 mmol) in water (100 mL). After the reaction mixture was refluxed for 3 h, the iron was filtered off and the filtrate was basified to pH 9 by addition of sodium carbonate. The reaction mixture was extracted with ethyl acetate (300 mL×2). The extract was washed with water (130 mL×2) and brine (130 mL×2), dried over anhydrous sodium sulfate. The solvent was removed in vacuo and the residue was purified by ISCO combi-flash chromatography (gradient elution, 20-60% ethyl acetate in petroleum ether) to afford 4-amino-N-cyclobutyl-benzenesulfonamide (3.87 g, 93%) as a yellow powder: MS (ESI) M+1=227.0.

Workup

  1. temperatureAfter the reaction mixture was refluxed for 3 h
  2. filtrationthe iron was filtered off
  3. additionthe filtrate was basified to pH 9 by addition of sodium carbonate
  4. extractionThe reaction mixture was extracted with ethyl acetate (300 mL×2)
  5. washThe extract was washed with water (130 mL×2) and brine (130 mL×2)
  6. dry with materialdried over anhydrous sodium sulfate
  7. customThe solvent was removed in vacuo
  8. customthe residue was purified by ISCO combi-flash chromatography (gradient elution, 20-60% ethyl acetate in petroleum ether)

Sources & evidence

ORD record
ord-daf9b3b37eef498fa6bbf21b6c3b4af0
Source dataset
uspto-grants-2014_08
Patent number
US08809369B2

Reaction notes

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