Hydrochloric Acid → HCID 67470557, compound

Participants

Reaction Conditions

Reaction Steps

To tent-butyl 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]-4-fluoropiperidine-1-carboxylate (8.80 g) was added, under an argon atmosphere at 0° C., a solution of hydrogen chloride in dioxane (4 M, 92 ml). The mixture was stirred at 0° C. and then slowly warmed to room temperature. After stirring for 24 hours, the excess acid and the solvent were removed under reduced pressure. This gave 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]-4-fluoropiperidinium chloride (7.70 g).

Provenance & Evidence