Hydrochloric Acid → HCID 67470557, compound

HRID 2408258Notes

Reaction equation

HRID 2408258 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([C:11]2([F:24])[CH2:16][CH2:15][N:14](C(OCCCC)=O)[CH2:13][CH2:12]2)[S:9][CH:10]=1)=[O:5])[CH3:2].[ClH:25]>O1CCOCC1>[Cl-:25].[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([C:11]2([F:24])[CH2:16][CH2:15][NH2+:14][CH2:13][CH2:12]2)[S:9][CH:10]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86660069HCID 86660069, compound

Product 1

HCID 67470557HCID 67470557, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
0 °C

Procedure

To tent-butyl 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]-4-fluoropiperidine-1-carboxylate (8.80 g) was added, under an argon atmosphere at 0° C., a solution of hydrogen chloride in dioxane (4 M, 92 ml). The mixture was stirred at 0° C. and then slowly warmed to room temperature. After stirring for 24 hours, the excess acid and the solvent were removed under reduced pressure. This gave 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]-4-fluoropiperidinium chloride (7.70 g).

Workup

  1. temperatureslowly warmed to room temperature
  2. stirringAfter stirring for 24 hours
  3. customthe excess acid and the solvent were removed under reduced pressure

Sources & evidence

ORD record
ord-1a16979e57a4478c80a8aea6c42c9a9d
Source dataset
uspto-grants-2014_08
Patent number
US08815775B2

Reaction notes

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