Water → (2S)-3,3,3-Trifluoro-2-methylpropane-1,2-diamine

Into a flask, are introduced 4.8 g of (2S)-3,3,3-trifluoro-2-methyl-propane-1,2-diamine hydrochloride, 2.5 mL of water and 100 mL of ethyl ether. 4.5 mL of 32% soda are added dropwise on the resulting mixture until pH=12. The aqueous phase is then decanted and then extracted 4 times with 200 mL of ethyl ether. The organic phases are collected, dried on magnesium sulfate, filtered and then concentrated under reduced pressure (300 mbars/bath temperature=25° C.) in order to obtain 2.3 g of (2S)-3,3,3-trifluoro-2-methyl-propane-1,2-diamine, as a pale yellow oil, including the following characteristics:

1. addition4.5 mL of 32% soda are added dropwise on the resulting mixture until pH=12
2. customThe aqueous phase is then decanted
3. extractionextracted 4 times with 200 mL of ethyl ether
4. customThe organic phases are collected
5. customdried on magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure (300 mbars/bath temperature=25° C.) in order

ORD record

ord-0998f1504fe74eaabb79b01bc71f1179

Source dataset

uspto-grants-2014_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08815853B2