Water → (2S)-3,3,3-Trifluoro-2-methylpropane-1,2-diamine

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Reaction Steps

Into a flask, are introduced 4.8 g of (2S)-3,3,3-trifluoro-2-methyl-propane-1,2-diamine hydrochloride, 2.5 mL of water and 100 mL of ethyl ether. 4.5 mL of 32% soda are added dropwise on the resulting mixture until pH=12. The aqueous phase is then decanted and then extracted 4 times with 200 mL of ethyl ether. The organic phases are collected, dried on magnesium sulfate, filtered and then concentrated under reduced pressure (300 mbars/bath temperature=25° C.) in order to obtain 2.3 g of (2S)-3,3,3-trifluoro-2-methyl-propane-1,2-diamine, as a pale yellow oil, including the following characteristics:

Provenance & Evidence