反应详情

To 250 mL of methanol under nitrogen, 5.21 g of sodium are added. Once dissolution is total and after returning to RT, 20 g of 5,5-dimethyl-4,5-dihydro-imidazol-2-amine bromide and 31.2 g of ethyl malonate are added. The medium is heated with reflux for 16 h. The reaction medium is dry concentrated, and then taken up in 40 mL of ice water. The expected product is precipitated by adding 1N HCl. The obtained precipitate is filtered, washed with water and then dried in the oven at 50° C. 18.62 g (yield=97%) of 7-hydroxy-2,2-dimethyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one are obtained as a white solid.

1. dissolutionOnce dissolution
2. customafter returning to RT
3. temperatureThe medium is heated
4. temperaturewith reflux for 16 h
5. customThe reaction medium is dry
6. concentrationconcentrated
7. customThe expected product is precipitated
8. additionby adding 1N HCl
9. filtrationThe obtained precipitate is filtered
10. washwashed with water
11. customdried in the oven at 50° C