Cyanogen Bromide → HCID 68034535, compound

HRID 2408340Notes

Reaction equation

HRID 2408340 reaction equation
[NH2:1][CH2:2][C:3]1([NH2:8])[CH2:7][CH2:6][CH2:5][CH2:4]1.Br[C:10]#[N:11]>O>[NH:8]1[C:3]2([CH2:7][CH2:6][CH2:5][CH2:4]2)[CH2:2][N:1]=[C:10]1[NH2:11]

Participants

4

Reactant 2

HCID 10476Cyanogen BromideHCID 1998181-Aminocyclopentanemethanamine

Product 1

HCID 68034535HCID 68034535, compoundYield 138.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.35 g of 1-(aminomethyl)cyclopentanamine are solubilized in 20 mL of water, cooled beforehand in an ice bath. 3.52 g of BrCN are added and the mixture is then stirred for 3 h at RT. The solvent is evaporated. 5.67 g (yield=88%) of 1,3-diazaspiro[4.4]non-2-en-2-amine are obtained as a brown oil.

Workup

  1. temperaturecooled
  2. custombeforehand in an ice bath
  3. customThe solvent is evaporated

Sources & evidence

ORD record
ord-c74b8b6268b8439d84098a1b63101773
Source dataset
uspto-grants-2014_08
Patent number
US08815853B2

Reaction notes

Loading…