Morpholine → HCID 57407135, compound

HRID 2408346Notes

Reaction equation

HRID 2408346 reaction equation
Cl[C:2]1[N:3]=[C:4]2[N:12]([CH2:13][CH2:14][O:15][CH3:16])[C:11]([CH3:18])([CH3:17])[CH2:10][CH2:9][N:5]2[C:6](=[O:8])[CH:7]=1.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[CH3:16][O:15][CH2:14][CH2:13][N:12]1[C:4]2=[N:3][C:2]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[CH:7][C:6](=[O:8])[N:5]2[CH2:9][CH2:10][C:11]1([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 67982473HCID 67982473, compound

Product 1

HCID 57407135HCID 57407135, compoundYield 58%

Procedure

0.07 g of 2-chloro-9-(2-methoxyethyl)-8,8-dimethyl-6,7,8,9-tetrahydro-4H-pyrimido-[1,2-a]pyrimidin-4-one in 2.5 mL of morpholine are heated with the microwave oven to 80° C. for 2 h. The crude is purified by flash chromatography on silica gel SiO2 (100% CH2Cl2 to 92/8 CH2Cl2/MeOH). 0.050 g (yield=58%) of 9-(2-methoxyethyl)-8,8-dimethyl-2-(morpholin-4-yl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]-pyrimidin-4-one are obtained as a white solid including the following characteristics:

Workup

  1. customThe crude is purified by flash chromatography on silica gel SiO2 (100% CH2Cl2 to 92/8 CH2Cl2/MeOH)

Sources & evidence

ORD record
ord-10db6383ad3c4b068483d1fd4c12fcc3
Source dataset
uspto-grants-2014_08
Patent number
US08815853B2

Reaction notes

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