Hydrazine hydrate (1:1) → HCID 89883778, compound

HRID 2408351Notes

Reaction equation

HRID 2408351 reaction equation
[CH2:1]([O:3][C:4](=[O:22])[NH:5][C:6]([CH3:21])([CH3:20])[CH2:7][CH2:8][N:9]1C(=O)C2C(=CC=CC=2)C1=O)[CH3:2].O.NN>C(O)C>[CH2:1]([O:3][C:4](=[O:22])[NH:5][C:6]([CH3:21])([CH3:20])[CH2:7][CH2:8][NH2:9])[CH3:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 68034541HCID 68034541, compound

Product 1

HCID 89883778HCID 89883778, compoundYield 95.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5.12 g of ethyl[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-1,1-dimethylpropyl]-carbamate are put into solution in 47 mL of ethanol. 4 mL of hydrazine hydrate are added and the mixture is refluxed for 30 minutes with heating. After returning to RT, the reaction medium is filtered and the solvent is then evaporated. 2.8 g (yield=88%) of ethyl(3-amino-1,1-dimethylpropyl)carbamate are obtained as a brown gum used as such.

Workup

  1. temperaturethe mixture is refluxed for 30 minutes
  2. temperaturewith heating
  3. customAfter returning to RT
  4. filtrationthe reaction medium is filtered
  5. customthe solvent is then evaporated

Sources & evidence

ORD record
ord-d6c550613e0249258920ffa9fa999694
Source dataset
uspto-grants-2014_08
Patent number
US08815853B2

Reaction notes

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