Morpholine → HCID 136344291, compound

HRID 2408357Notes

Reaction equation

HRID 2408357 reaction equation
Cl[C:2]1[N:3]=[C:4]2[NH:12][CH2:11][C:10]([CH3:14])([CH3:13])[CH2:9][N:5]2[C:6](=[O:8])[CH:7]=1.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[CH3:13][C:10]1([CH3:14])[CH2:9][N:5]2[C:6](=[O:8])[CH:7]=[C:2]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)[N:3]=[C:4]2[NH:12][CH2:11]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 136344292HCID 136344292, compound

Product 1

HCID 136344291HCID 136344291, compoundYield 62%

Procedure

0.7 g of 2-chloro-7,7-dimethyl-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one in 5 mL of morpholine are heated in the microwave oven to 80° C. for 1 h30 mins. The crude is purified by flash chromatography on silica gel SiO2 (100% CH2Cl2 to 92/8 CH2Cl2/MeOH). 0.58 g (yield=62%) of 7,7-dimethyl-2-(morpholin-4-yl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one are obtained as a white solid including the following characteristics:

Workup

  1. customThe crude is purified by flash chromatography on silica gel SiO2 (100% CH2Cl2 to 92/8 CH2Cl2/MeOH)

Sources & evidence

ORD record
ord-dcb9990a5d4c4c4d83bef619578c9d7e
Source dataset
uspto-grants-2014_08
Patent number
US08815853B2

Reaction notes

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