HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guanidine Hydrochloride → 5,5-Dimethyl-1,4,5,6-tetrahydropyrimidin-2-amine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guanidine Hydrochloride | HCID 5742 | — |
| Reactant | 2,2-Dimethyl-1,3-propanediamine | HCID 81770 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5,5-Dimethyl-1,4,5,6-tetrahydropyrimidin-2-amine hydrochloride | HCID 23466245 | 104.9% |
Reaction Steps
2.5 g of 2,2-dimethylpropane-1,3-diamine and 2.17 g of guanidine hydrochloride are heated to 140° C. under argon for 4 h. After returning to RT, add ethanol and dry evaporate. 3.9 g (yield=95%) of 5,5-dimethyl-1,4,5,6-tetrahydropyrimidin-2-amine hydrochloride are obtained as a white powder used as such.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815853B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-d9d04e8bc97d4124a792669e4cd6a078 |
| Source note | uspto-grants-2014_08 |