Guanidine Hydrochloride → 5,5-Dimethyl-1,4,5,6-tetrahydropyrimidin-2-amine hydrochloride

HRID 2408359Notes

Reaction equation

HRID 2408359 reaction equation
[CH3:1][C:2]([CH3:7])([CH2:5][NH2:6])[CH2:3][NH2:4].[ClH:8].[NH2:9][C:10](N)=N>C(O)C>[ClH:8].[CH3:1][C:2]1([CH3:7])[CH2:5][NH:6][C:10]([NH2:9])=[N:4][CH2:3]1

Participants

4

Reactant 2

HCID 5742Guanidine HydrochlorideHCID 817702,2-Dimethyl-1,3-propanediamine

Product 1

HCID 234662455,5-Dimethyl-1,4,5,6-tetrahydropyrimidin-2-amine hydrochlorideYield 104.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.5 g of 2,2-dimethylpropane-1,3-diamine and 2.17 g of guanidine hydrochloride are heated to 140° C. under argon for 4 h. After returning to RT, add ethanol and dry evaporate. 3.9 g (yield=95%) of 5,5-dimethyl-1,4,5,6-tetrahydropyrimidin-2-amine hydrochloride are obtained as a white powder used as such.

Workup

  1. customAfter returning to RT
  2. customdry
  3. customevaporate

Sources & evidence

ORD record
ord-d9d04e8bc97d4124a792669e4cd6a078
Source dataset
uspto-grants-2014_08
Patent number
US08815853B2

Reaction notes

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