Hydrochloric Acid → HCID 15985975, compound

HRID 2408434Notes

Reaction equation

HRID 2408434 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[CH:8]=[C:9]([S:13]([N:16]3[CH:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[C:23]([NH:25][O:26]C4CCCCO4)=[O:24])=[CH:17]3)(=[O:15])=[O:14])[CH:10]=[CH:11][CH:12]=2)[CH:4]=[N:3]1.Cl>CO>[OH:26][NH:25][C:23](=[O:24])/[CH:22]=[CH:21]/[C:18]1[CH:19]=[CH:20][N:16]([S:13]([C:9]2[CH:10]=[CH:11][CH:12]=[C:7]([C:5]3[CH:4]=[N:3][N:2]([CH3:1])[CH:6]=3)[CH:8]=2)(=[O:15])=[O:14])[CH:17]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86621685HCID 86621685, compound

Product 1

HCID 15985975HCID 15985975, compoundYield 64.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 0.086 g (E)-3-{1-[3-(1-methyl-1H-pyrazol-4-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-N-(tetrahydro-pyran-2-yloxy)-acrylamide with 3.0 ml methanol and 7.0 ml 1M aqueous HCl is stirred at ambient temperature for 24 h. The suspension is partly evaporated and the residual mixture is centrifuged. The product is washed with water and diisopropylether and dried in vacuo. By this method 0.045 g of a light pink powder are obtained. Melting point: 155-160° C., sinter is beginning from 85° C.

Workup

  1. customThe suspension is partly evaporated
  2. washThe product is washed with water and diisopropylether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-185e03522d814abface8a5945736aa18
Source dataset
uspto-grants-2014_08
Patent number
US08815855B2

Reaction notes

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