Hydrochloric Acid → HCID 15986052, compound

HRID 2408435Notes

Reaction equation

HRID 2408435 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]1[CH:17]=[CH:16][C:15]([S:18]([N:21]2[CH:25]=[CH:24][C:23](/[CH:26]=[CH:27]/[C:28]([NH:30][O:31]C3CCCCO3)=[O:29])=[CH:22]2)(=[O:20])=[O:19])=[CH:14][CH:13]=1)(=[O:4])=[O:3].Cl>CO>[OH:31][NH:30][C:28](=[O:29])/[CH:27]=[CH:26]/[C:23]1[CH:24]=[CH:25][N:21]([S:18]([C:15]2[CH:14]=[CH:13][C:12]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=3[NH:5][S:2]([CH3:1])(=[O:4])=[O:3])=[CH:17][CH:16]=2)(=[O:19])=[O:20])[CH:22]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86621686HCID 86621686, compound

Product 1

HCID 15986052HCID 15986052, compoundYield 43.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 0.220 g (E)-3-[1-(2′-methanesulfonylamino-biphenyl-4-sulfonyl)-1H-pyrrol-3-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide with 6.0 ml methanol and 13.0 ml 1M aqueous HCl is stirred at ambient temperature for 24 h. During evaporation the product starts to crystallize. The crystals are washed with water and diisopropylether. The crude product is purified by PLC plates chromatography. By this method 0.081 g of a red oil are obtained.

Workup

  1. customDuring evaporation the product
  2. customto crystallize
  3. washThe crystals are washed with water and diisopropylether
  4. customThe crude product is purified by PLC plates chromatography

Sources & evidence

ORD record
ord-2dfbf620c04044eda293ada43e6cf846
Source dataset
uspto-grants-2014_08
Patent number
US08815855B2

Reaction notes

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