Hydrochloric Acid → HCID 15986053, compound

HRID 2408436Notes

Reaction equation

HRID 2408436 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[C:8]([C:12]2[CH:17]=[CH:16][C:15]([S:18]([N:21]3[CH:25]=[CH:24][C:23](/[CH:26]=[CH:27]/[C:28]([NH:30][O:31]C4CCCCO4)=[O:29])=[CH:22]3)(=[O:20])=[O:19])=[CH:14][CH:13]=2)[CH:9]=[CH:10][CH:11]=1)(=[O:4])=[O:3].Cl>CO>[OH:31][NH:30][C:28](=[O:29])/[CH:27]=[CH:26]/[C:23]1[CH:24]=[CH:25][N:21]([S:18]([C:15]2[CH:14]=[CH:13][C:12]([C:8]3[CH:9]=[CH:10][CH:11]=[C:6]([NH:5][S:2]([CH3:1])(=[O:4])=[O:3])[CH:7]=3)=[CH:17][CH:16]=2)(=[O:19])=[O:20])[CH:22]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86621687HCID 86621687, compound

Product 1

HCID 15986053HCID 15986053, compoundYield 41.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 0.334 g (E)-3-[1-(3′-methanesulfonylamino-biphenyl-4-sulfonyl)-1H-pyrrol-3-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide with 11.0 ml methanol and 18.0 ml 1M aqueous HCl is stirred for 48 h. The suspension is evaporated and the solid is isolated and washed with water and diisopropylether. The crude product is purified by PLC plates chromatography. By this method 0.116 g of a red solid are obtained. Melting point: 137-148° C.

Workup

  1. customThe suspension is evaporated
  2. customthe solid is isolated
  3. washwashed with water and diisopropylether
  4. customThe crude product is purified by PLC plates chromatography

Sources & evidence

ORD record
ord-b3cdb42096ec4779b5f1e961d1274cf0
Source dataset
uspto-grants-2014_08
Patent number
US08815855B2

Reaction notes

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