HCID 68528117, compound → HCID 68526678, compound

HRID 2408458Notes

Reaction equation

HRID 2408458 reaction equation
C([O:5][C:6](=[O:24])/[CH:7]=[CH:8]/[C:9]1[CH:13]=[CH:12][N:11]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([I:23])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH:10]=1)(C)(C)C>ClCCl.C(O)(C(F)(F)F)=O>[I:23][C:20]1[CH:19]=[CH:18][C:17]([S:14]([N:11]2[CH:12]=[CH:13][C:9](/[CH:8]=[CH:7]/[C:6]([OH:24])=[O:5])=[CH:10]2)(=[O:16])=[O:15])=[CH:22][CH:21]=1

Participants

4

Reactant 1

HCID 68528117HCID 68528117, compound

Product 1

HCID 68526678HCID 68526678, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture of 6.69 g (E)-3-[1-(4-Iodo-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester in 180 ml dichloromethane and 18.1 ml TFA is stirred at ambient temperature over the weekend. The reaction mixture is evaporated and the crude product is washed with toluene and dried in vacuo.

Workup

  1. customThe reaction mixture is evaporated
  2. washthe crude product is washed with toluene
  3. customdried in vacuo

Sources & evidence

ORD record
ord-c5ff14410e334fb1993fd311433ba6fe
Source dataset
uspto-grants-2014_08
Patent number
US08815855B2

Reaction notes

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