Trifluoroacetic acid → HCID 68525252, compound

HRID 2408461Notes

Reaction equation

HRID 2408461 reaction equation
C([O:5][C:6](=[O:23])/[CH:7]=[CH:8]/[C:9]1[CH:13]=[CH:12][N:11]([S:14]([C:17]2[S:18][C:19]([Br:22])=[CH:20][CH:21]=2)(=[O:16])=[O:15])[CH:10]=1)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[Br:22][C:19]1[S:18][C:17]([S:14]([N:11]2[CH:12]=[CH:13][C:9](/[CH:8]=[CH:7]/[C:6]([OH:23])=[O:5])=[CH:10]2)(=[O:15])=[O:16])=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68527901HCID 68527901, compound

Product 1

HCID 68525252HCID 68525252, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 4.5 g (E)-3-[1-(5-bromo-thiophene-2-sulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester with 85.0 ml dichloromethane and 13.0 ml TFA is stirred at ambient temperature for 24 h. The dichloromethane and TEA is evaporated and the residue is coevaporated with toluene for 3 times. By this method 3.8 g light pink solid is obtained.

Workup

  1. customThe dichloromethane and TEA is evaporated

Sources & evidence

ORD record
ord-dbc68a7f269d4a5baac13395dcd18eef
Source dataset
uspto-grants-2014_08
Patent number
US08815855B2

Reaction notes

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