反应详情

Trifluoroacetic acid (46 μL, 0.059 mmol) was added to a mixture solution of tert-butyl 4-(3-(4-methoxyphenyl)-1-(pyridin-4-yl)-1H-indol-6-yl)piperazine-1-carboxylate (29 mg, 0.059 mmol) in methylene chloride (1 mL) at room temperature. After stirring for 3 hours, the reaction solution was concentrated under reduced pressure. After adding ethyl acetate and saturated sodium bicarbonate aqueous solution, the mixture was extracted with ethyl acetate. The collected organic layer was washed with brine and concentrated under reduced pressure by drying with anhydrous magnesium sulfate. The target compound (14 mg, 64%) was obtained as yellow solid.

1. concentrationthe reaction solution was concentrated under reduced pressure
2. additionAfter adding ethyl acetate and saturated sodium bicarbonate aqueous solution
3. extractionthe mixture was extracted with ethyl acetate
4. washThe collected organic layer was washed with brine
5. concentrationconcentrated under reduced pressure
6. dry with materialby drying with anhydrous magnesium sulfate