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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2408507Generated: November 1, 2026

1-[4-Amino-3-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-cyclohexanecarbonitrile → 4-Cyano-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylic acid [4-(1-cyano-cyclohexyl)-2-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-amide

https://huagongshe.com/reaction/2408507

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-[4-Amino-3-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-cyclohexanecarbonitrileHCID 58993717—
Reactantpotassium 4-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylateHCID 67188357—
Product4-Cyano-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylic acid [4-(1-cyano-cyclohexyl)-2-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-amideHCID 58993758—

Reaction Steps

The title compound was prepared from 1-[4-amino-3-(4,4-dimethyl-cyclohex-1-enyl)-phenyl]-cyclohexanecarbonitrile (as prepared in the previous step) and 4-cyano-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylate potassium salt (as prepared in Example 1, step (d)) according to the procedure of Example 1, step (f). Mass spectrum (ESI, m/z): Calcd. for C32H43N5O2Si, 558.3 (M+H), found 557.8.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08815867B2
Source datasetuspto-grants-2014_08
ORD IDord-46c5896c01124a3ebcc922449833fcf9
Source noteuspto-grants-2014_08