HCID 24826698, compound → HCID 24826778, compound

HRID 2408510Notes

Reaction equation

HRID 2408510 reaction equation
[CH3:1][C:2]1([CH3:35])[CH2:7][CH2:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]3([OH:24])[CH2:19][CH2:18][C:17](OC)([O:20]C)[CH2:16][CH2:15]3)[CH:11]=[CH:10][C:9]=2[NH:25][C:26]([C:28]2[NH:29][C:30]([C:33]#[N:34])=[CH:31][N:32]=2)=[O:27])=[CH:4][CH2:3]1>CC#N>[CH3:1][C:2]1([CH3:35])[CH2:7][CH2:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]3([OH:24])[CH2:15][CH2:16][C:17](=[O:20])[CH2:18][CH2:19]3)[CH:11]=[CH:10][C:9]=2[NH:25][C:26]([C:28]2[NH:29][C:30]([C:33]#[N:34])=[CH:31][N:32]=2)=[O:27])=[CH:4][CH2:3]1

Participants

3

Reactant 1

HCID 24826698HCID 24826698, compound

Product 1

HCID 24826778HCID 24826778, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound is prepared from 5-cyano-1H-imidazole-2-carboxylic acid [2-(4,4-dimethyl-cyclohex-1-enyl)-4-(1-hydroxy-4,4-dimethoxy-cyclohexyl)-phenyl]-amide (as prepared in Example 19) by treatment with LiBF4 in wet CH3CN using the procedure of Lipshutz, B. and Harvey, D., Synth. Commun., 12, 267 (1982).

Sources & evidence

ORD record
ord-ac240aeac76c4f5a91d01c2f7f0f1fdc
Source dataset
uspto-grants-2014_08
Patent number
US08815867B2

Reaction notes

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