Potassium Carbonate → HCID 86720114, compound

HRID 2408541Notes

Reaction equation

HRID 2408541 reaction equation
[CH3:1][O:2][C:3](=[O:26])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([OH:25])[CH:20]=[CH:21][C:22]=4[F:24])[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1.Cl[C:28]1[N:32]([CH3:33])[C:31]2[CH:34]=[CH:35][CH:36]=[CH:37][C:30]=2[N:29]=1.C([O-])([O-])=O.[K+].[K+]>C(#N)C>[CH3:1][O:2][C:3](=[O:26])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([O:25][C:28]5[N:32]([CH3:33])[C:31]6[CH:34]=[CH:35][CH:36]=[CH:37][C:30]=6[N:29]=5)[CH:20]=[CH:21][C:22]=4[F:24])[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 6630802-chloro-1-methyl-1H-1,3-benzodiazoleHCID 86720104[(S)-6-((R)-7-Fluoro-4-hydroxyindan-1-yloxy)-2,3-dihydrobenzofuran-3-yl]-acetic acid methyl ester

Product 1

HCID 86720114HCID 86720114, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound is prepared from {(S)-6-[(R)-7-fluoro-4-hydroxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 2-chloro-1-methyl-1H-benzoimidazole following a procedure analogous to that described for Intermediate 12; K2CO3 and acetonitrile are used as base and solvent, respectively, at 110° C. LC (method 4): tR=0.72 min; Mass spectrum (ESI+): m/z=489 [M+H]+.

Workup

  1. customat 110° C

Sources & evidence

ORD record
ord-d543254ae39c47989ad624c681d39527
Source dataset
uspto-grants-2014_08
Patent number
US08815864B2

Reaction notes

Loading…