HCID 50991730, compound → HCID 50991731, compound

HRID 240855Notes

Reaction equation

HRID 240855 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:18]=[C:17]3[C:13]([C:14]([C:25]4[CH:30]=[CH:29][C:28]([OH:31])=[CH:27][CH:26]=4)=[CH:15][N:16]3[C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O>[C].[Pd].CO>[NH2:1][C:4]1[CH:5]=[C:6]([C:10]2[CH:18]=[C:17]3[C:13]([C:14]([C:25]4[CH:30]=[CH:29][C:28]([OH:31])=[CH:27][CH:26]=4)=[CH:15][N:16]3[C:19]3[CH:20]=[CH:21][N:22]=[CH:23][CH:24]=3)=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 50991730HCID 50991730, compound

Product 1

HCID 50991731HCID 50991731, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Methanol (2 mL) was added to 4-(6-(3-nitrophenyl)-1-(pyridin-4-yl)-1H-indol-3-yl)phenol (4.6 mg, 0.0113 mmol) and 10% (w/w) palladium-carbon (Pd—C, 5.0 mg). The mixture was stirred at room temperature for 12 hours under hydrogen gas (1 atm). The reaction solution was filtered using a diatomite pad and concentrated under reduced pressure. The target compound was obtained as brown solid.

Workup

  1. filtrationThe reaction solution was filtered
  2. concentrationconcentrated under reduced pressure
  3. customThe target compound was obtained as brown solid

Sources & evidence

ORD record
ord-79b912f6b90e4bbfaaaacb034909eac0
Source dataset
uspto-grants-2014_02
Patent number
US08648089B2

Reaction notes

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