反应详情

1 M aqueous NaOH solution (3.0 mL) is added to a solution of {(S)-6-[(R)-7-fluoro-4-phenoxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester (0.18 g) in methanol (6 mL) and tetrahydrofuran (6 mL) at room temperature. The mixture is stirred at room temperature for 4 h. The organic solvent is evaporated, water (2 mL) is added, and the resulting solution is neutralized with 1 M aqueous HCl solution (3 mL). The solution is stirred at room temperature for 1 h. The precipitate is separated by filtration, washed with water and dried to give the title compound (if the compound does not precipitate, the solution is concentrated and the residue is purified by HPLC on reversed phase using acetonitrile, water and ammonia as eluent). LC (method 3): tR=1.14 min; Mass spectrum (ESI−): m/z=419 [M−H]−.

1. customThe organic solvent is evaporated
2. additionwater (2 mL) is added
3. stirringThe solution is stirred at room temperature for 1 h
4. customThe precipitate is separated by filtration
5. washwashed with water
6. customdried